Pavilion Health Today
Supporting healthcare professionals to deliver the best patient care

Data from PREFER in AF patient registry reveals increased stroke risk among diabetes patients in atrial fibrillation

Analysis of the PREvention oF thromboembolic events€”European Registry in Atrial Fibrillation (PREFER in AF) patient registry has revealed people with diabetes in atrial fibrillation have an increased risk of stroke.

DiabetesAnalysis of the PREvention oF thromboembolic events—European Registry in Atrial Fibrillation (PREFER in AF) patient registry has revealed people with diabetes in atrial fibrillation have an increased risk of stroke.

The analysis, sponsored by Daiichi Sankyo Europe GmbH, was presented at the ESC Congress 2016, which this year takes place in Rome, Italy.

The registry provides unique insights on recent developments in AF management across Europe and the current treatment challenges, helping to bolster the body of evidence of AF patient outcomes in a clinical setting. 

Sponsored by Daiichi Sankyo, the registry informs on AF patient profiles in a real-world clinical context, helping to identify specific at-risk patient groups, including those with co-morbidities that predispose them to thrombotic events. 

Data from the registry reveals that AF patients with diabetes, on insulin treatment are at a significantly increased risk of stroke/systemic embolism at one year follow-up compared to AF patients without diabetes and compared to those with diabetes not on insulin treatment. Diabetic patients not receiving insulin therapy had similar incidence of thromboembolic events than patients without diabetes.

Dr Giuseppe Patti, Campus Bio-Medico University, Rome, Italy and lead author of the study, said: “These results are greatly beneficial to physicians in clinical practice.

“The burden of AF is a considerable healthcare issue which carries a heightened risk of stroke for over six million sufferers in Europe. The availability of robust, real-world data to inform on patients at even greater risk of stroke or systemic embolism, will help identify where specific care is needed to minimise these outcomes.” 

The registry has also enabled a comparison of specific patient characteristics such as gender alongside clinical aspects including therapy choice and clinical outcomes. The registry has revealed that women experience a greater burden of symptoms compared to men and that treatment with oral anticoagulation is similar in both genders. Compared to men, women were found to be at 65% lower age and country-adjusted risk of coronary revascularisation at one year and 20% lower risk of chronic heart insufficiency/reduced left ventricular ejection fraction. There was no evidence that men and women differed in stroke, transient ischaemic attack, arterial thromboembolic events and major bleeding events over one year. 

While the results provide an indication of gender differences, further research is needed to establish whether this can be used to enhance AF management, determining prevention and treatment needs. 

Dr Juan-Carlos Jaramillo, Senior Vice President, Head of Market Access & Medical Affairs, Daiichi Sankyo Europe GmbH, said: “AF represents a significant concern across Europe, and we are pleased that the PREFER in AF registry sheds light on the current management of AF in a clinical setting, through delivery of this additional sub-study data. 

“By adding to the data available in this important disease area, Daiichi Sankyo is committed to supporting advancement in cardiovascular medicine and improvements in patient care.”

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read more ...

Privacy & Cookies Policy